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HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells.

Abstract:

BACKGROUND: The response rate to EGFR tyrosine kinase inhibitors (TKIs) may be poor and unpredictable in cancer patients with EGFR expression itself being an inadequate response indicator. There is limited understanding of the mechanisms underlying this resistance. Furthermore, although TKIs suppress the growth of HER2-overexpressing breast tumor cells, they do not fully inhibit HER2 oncogenic function at physiological doses. METHODOLOGY AND PRINCIPAL FINDINGS: Here we have provided a molecu...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0002881

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Molecular Medicine
Calleja, V More by this author
Leboucher, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Biomedical Research Centre, Molecular Medicine
Parker, PJ More by this author
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Journal:
PloS one
Volume:
3
Issue:
8
Pages:
e2881
Publication date:
2008
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:20624d40-def6-4e0a-8ca3-3cd6d8c1e2f0
Source identifiers:
125085
Local pid:
pubs:125085

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