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The mathematical modelling of adjuvant chemotherapy scheduling: incorporating the effects of protocol rest phases and pharmacokinetics.

Abstract:

In this paper the modelling objective is to determine the drug alternation time which minimises the formation of resistant tumour cells when delivering two non-cross resistant chemotherapeutics given such drugs cannot be delivered simultaneously and constraints due to pharmacokinetics and protocol rest phases. We initially consider cell cycle phase non-specific models, as investigated by Goldie and Coldman. By extending previous work, these models are generalised to consider chemotherapeutic ...

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Publication status:
Published

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Publisher copy:
10.1016/j.bulm.2004.09.002

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Journal:
Bulletin of mathematical biology
Volume:
67
Issue:
3
Pages:
563-611
Publication date:
2005-05-05
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
URN:
uuid:2055c591-deca-4aab-b1c1-203e306ccf01
Source identifiers:
26594
Local pid:
pubs:26594

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