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Alpha 2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic beta-cells.

Abstract:

The effects of alpha 2-adrenergic stimulation on the Ca(2+)-current in mouse pancreatic beta-cells were investigated using the patch-clamp technique. When using the conventional whole-cell recording configuration (dialysis of cell interior with pipette solution), addition of adrenaline (1 microM) or the alpha 2-adrenergic agonist clonidine (5 microM) failed to reduce the Ca(2+)-current, irrespective of whether intracellular GTP (or GTP gamma S) was present or not and at both physiological (1....

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Publication status:
Published

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Publisher copy:
10.1007/bf01182483

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
Bioscience reports
Volume:
11
Issue:
3
Pages:
147-157
Publication date:
1991-06-05
DOI:
EISSN:
1573-4935
ISSN:
0144-8463
URN:
uuid:205365fa-82a2-43c3-81e2-57e30b04343d
Source identifiers:
24325
Local pid:
pubs:24325

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