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Native functionality and therapeutic targeting of arenaviral glycoproteins.

Abstract:

Surface glycoproteins direct cellular targeting, attachment, and membrane fusion of arenaviruses and are the primary target for neutralizing antibodies. Despite significant conservation of the glycoprotein architecture across the arenavirus family, there is considerable variation in the molecular recognition mechanisms used during host cell entry. We review recent progress in dissecting these infection events and describe how arenaviral glycoproteins can be targeted by small-molecule antivira...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.coviro.2016.04.001

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Corpus Christi College
Role:
Author
ORCID:
0000-0002-1072-2694
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Role:
Author
ORCID:
0000-0002-5485-5480
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Merton College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Role:
Author
Neutralizing Antibody Consortium More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Current Opinion in Virology Journal website
Volume:
18
Pages:
70-75
Publication date:
2016-04-05
Acceptance date:
2016-04-04
DOI:
EISSN:
1879-6265
ISSN:
1879-6257
Pubs id:
pubs:613759
URN:
uri:2044485d-e4a8-44df-991f-b27c0213db3d
UUID:
uuid:2044485d-e4a8-44df-991f-b27c0213db3d
Local pid:
pubs:613759

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