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Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression.

Abstract:

The tissue-specific regulation of the cystic fibrosis transmembrane conductance regulator gene (CFTR) is coordinated by intronic and extragenic cis-acting elements that influence its transcriptional activity. The promoter apparently lacks sequences to drive cell type-specific expression. We previously identified a number of intronic elements that were associated with DNase I hypersensitive sites (DHS) and bound the hepatocyte nuclear factor 1 (HNF1) transcription factor. Moreover, we demonstr...

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Publication status:
Published

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Authors


McCarthy, VA More by this author
Phylactides, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Biomedical Research Centre, Molecular Medicine
Journal:
Biochimica et biophysica acta
Volume:
1789
Issue:
11-12
Pages:
709-718
Publication date:
2009
DOI:
EISSN:
1876-4320
ISSN:
0006-3002
URN:
uuid:2039b512-2520-4432-8855-df017c84017c
Source identifiers:
124795
Local pid:
pubs:124795

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