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Outcome of azacitidine therapy in acute myeloid leukemia is not improved by concurrent vorinostat therapy but is predicted by a diagnostic molecular signature

Abstract:
Purpose: Azacitidine (AZA) is a novel therapeutic option in older patients with acute myeloid leukemia (AML), but its rational utilization is compromised by the fact that neither the determinants of clinical response nor its mechanism of action are defined. Co-administration of histone deacety... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1158/1078-0432.ccr-17-1423

Authors


Craddock, CF More by this author
Houlton, AE More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Institute of Molecular Medicine
Ferguson, P More by this author
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Clinical Cancer Research Journal website
Volume:
23
Issue:
21
Pages:
6430-6440
Publication date:
2017-08-01
Acceptance date:
2017-07-26
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Pubs id:
pubs:710779
URN:
uri:2037f1f0-35f3-408b-bc2e-7800594ab946
UUID:
uuid:2037f1f0-35f3-408b-bc2e-7800594ab946
Local pid:
pubs:710779

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