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Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.

Abstract:

BACKGROUND: β2 -Glycoprotein I (β2 -GPI), also designated apolipoprotein H, is a 50-kDa protein that circulates in blood at high concentrations, playing important roles in autoimmune diseases, hemostasis, atherogenesis, and angiogenesis, as well as in host defense against bacteria and in protein/cellular waste removal. Plasma β2 -GPI levels have a significant genetic component (heritability of ~ 80%). OBJECTIVES: To present the results of a genome-wide association study for plasma β2 -GPI le...

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Publication status:
Published

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Publisher copy:
10.1111/jth.12120

Authors


Athanasiadis, G More by this author
Sabater-Lleal, M More by this author
Borrell, M More by this author
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Journal:
Journal of thrombosis and haemostasis : JTH
Volume:
11
Issue:
3
Pages:
521-528
Publication date:
2013-03-05
DOI:
EISSN:
1538-7836
ISSN:
1538-7933
URN:
uuid:201d40e0-f6c2-436b-836b-3229a0b7a654
Source identifiers:
394159
Local pid:
pubs:394159

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