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Journal article

GATA transcription factors integrate Wnt signalling during heart development.

Abstract:

Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate ...

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Publication status:
Published

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Publisher copy:
10.1242/dev.026443

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, BHF Centre of Research Excellence
Role:
Author
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Journal:
Development (Cambridge, England)
Volume:
135
Issue:
19
Pages:
3185-3190
Publication date:
2008-10-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:200b935e-0e57-42d4-bdaa-5f7209e3f8d8
Source identifiers:
106359
Local pid:
pubs:106359

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