- Abstract:
-
Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1242/dev.026443
-
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- Journal:
- Development (Cambridge, England)
- Volume:
- 135
- Issue:
- 19
- Pages:
- 3185-3190
- Publication date:
- 2008-10-05
- DOI:
- EISSN:
-
1477-9129
- ISSN:
-
0950-1991
- URN:
-
uuid:200b935e-0e57-42d4-bdaa-5f7209e3f8d8
- Source identifiers:
-
106359
- Local pid:
- pubs:106359
- Copyright date:
- 2008
Journal article
GATA transcription factors integrate Wnt signalling during heart development.
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