Pore geometry regulates early stage human bone marrow cell tissue formation and organisation.

Journal article

Porous architecture has a dramatic effect on tissue formation in porous biomaterials used in regenerative medicine. However, the wide variety of 3D structures used indicates there is a clear need for the optimal design of pore architecture to maximize tissue formation and ingrowth. Thus, the aim of this study was to characterize initial tissue growth solely as a function of pore geometry. We used an in vitro system with well-defined open pore slots of varying width, providing a 3D environment...

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Authors: Knychala, J; Bouropoulos, N; Catt, C; Katsamenis, O; Please, C

• Publication status: Published
• Journal: Annals of biomedical engineering
• Volume: 41
• Issue: 5
• Pages: 917-930
• Publication date: 2013-05-01
• DOI: 10.1007/s10439-013-0748-z
• EISSN: 1573-9686
• ISSN: 0090-6964
• Language: English
• Keywords: Bone Marrow Cells; Bone Cements; Cells, Cultured; Male; Models, Biological; Humans; Porosity; Bone and Bones; Bone Substitutes; Tissue Engineering; Aged, 80 and over