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Will telomere erosion lead to a loss of T-cell memory?

Abstract:
Evidence is accumulating that elderly individuals are more susceptible to infection with organisms to which they were previously immune. This indicates that there might be a limit to the persistence of immune memory. This fact is particularly disturbing because the average life expectancy of humans has almost doubled in the past 200 years and is still increasing. We discuss mechanisms that might constrain the persistence of memory T cells and consider whether humans will suffer from memory T-cell exhaustion as life expectancy increases.

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Publisher copy:
10.1038/nri1440

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Nature reviews. Immunology
Volume:
4
Issue:
9
Pages:
737-743
Publication date:
2004-09-05
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
URN:
uuid:1fe06eae-f0a0-41dd-93ff-252ad3f0085d
Source identifiers:
32835
Local pid:
pubs:32835

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