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The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary

Abstract:

The short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein superfamilies known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobiotics. We have currently identified 73 SDR superfamily members within the human genome. A status report of the human SDR superfamily is provided in terms of 3D structure determination, co-factor pre...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cbi.2008.10.058

Authors


Publisher:
Elsevier Publisher's website
Journal:
Chemico-Biological Interactions Journal website
Volume:
178
Issue:
1-3
Pages:
99-109
Publication date:
2009-01-01
DOI:
EISSN:
1872-7786
ISSN:
0009-2797
URN:
uuid:1fdaa758-deca-45b1-9f35-27e1f9164907
Local pid:
SGC:19061874

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