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Myocardial regeneration: expanding the repertoire of thymosin β4 in the ischemic heart.

Abstract:

Efficient cardiac regeneration postinfarction (MI) requires the replacement of lost cardiomyocytes, formation of new coronary vessels and appropriate modulation of the inflammatory response. However, insight into how to stimulate repair of the human heart is currently limited. Using the embryonic paradigm of regeneration, we demonstrated that the actin-binding peptide thymosin β4 (Tβ4), required for epicardium-derived coronary vasculogenesis, can recapitulate its embryonic role and activate q...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Bollini, S More by this author
Vieira, JM More by this author
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Journal:
Annals of the New York Academy of Sciences
Volume:
1269
Issue:
1
Pages:
92-101
Publication date:
2012-10-05
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
URN:
uuid:1fcec890-1bf0-4acd-acf9-ca8e6fa12c75
Source identifiers:
354067
Local pid:
pubs:354067

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