Journal article icon

Journal article

Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.

Abstract:

Celiac disease is a genetic condition that results in a debilitating immune reaction in the gut to antigens in grain. The antigenic peptides recognized by the T cells that cause this disease are incompletely defined. Our understanding of the epitopes of pathogenic CD4(+ )T cells is based primarily on responses shown by intestinal T-cells in vitro to hydrolysates or polypeptides of gluten, the causative antigen. A protease-resistant 33-amino acid peptide from wheat alpha-gliadin is the immunod...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Science translational medicine
Volume:
2
Issue:
41
Pages:
41ra51
Publication date:
2010-07-05
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
URN:
uuid:1fcd70f9-d7f2-4e9c-b4b1-e3c99e82e82d
Source identifiers:
94840
Local pid:
pubs:94840

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP