- Abstract:
-
The basis of chronic infection following exposure to hepatitis C virus (HCV) infection is unexplained. One factor may be the low frequency and immature phenotype of virus-specific CD8(+) T cells. The role of CD4(+)CD25(+) T regulatory (T(reg)) cells in priming and expanding virus-specific CD8(+) T cells was investigated. Twenty HLA-A2-positive patients with persistent HCV infection and 46 healthy controls were studied. Virus-specific CD8(+) T-cell proliferation and gamma interferon (IFN-gamma...
Expand abstract - Publisher copy:
- 10.1128/jvi.79.12.7852-7859.2005
-
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- Journal:
- Journal of virology
- Volume:
- 79
- Issue:
- 12
- Pages:
- 7852-7859
- Publication date:
- 2005-06-05
- DOI:
- EISSN:
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1098-5514
- ISSN:
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0022-538X
- URN:
-
uuid:1fc404f8-ffbb-4494-94e1-ceffbce1a991
- Source identifiers:
-
4804
- Local pid:
- pubs:4804
- Copyright date:
- 2005
Journal article
Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection.
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