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Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection.

Abstract:

The basis of chronic infection following exposure to hepatitis C virus (HCV) infection is unexplained. One factor may be the low frequency and immature phenotype of virus-specific CD8(+) T cells. The role of CD4(+)CD25(+) T regulatory (T(reg)) cells in priming and expanding virus-specific CD8(+) T cells was investigated. Twenty HLA-A2-positive patients with persistent HCV infection and 46 healthy controls were studied. Virus-specific CD8(+) T-cell proliferation and gamma interferon (IFN-gamma...

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Journal:
Journal of virology
Volume:
79
Issue:
12
Pages:
7852-7859
Publication date:
2005-06-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:1fc404f8-ffbb-4494-94e1-ceffbce1a991
Source identifiers:
4804
Local pid:
pubs:4804

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