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Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation.

Abstract:

GDF8, or myostatin, is a member of the TGF-β superfamily of secreted polypeptide growth factors. GDF8 is a potent negative regulator of myogenesis both in vivo and in vitro. We found that GDF8 signaling was inhibited by the small molecule ATP competitive inhibitors Dorsomorphin and LDN-193189. These compounds were previously shown to be potent inhibitors of BMP signaling by binding to the type BMP type I receptors ALK1/2/3/6. We present the crystal structure of the type II receptor ActRIIA wi...

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Publisher copy:
10.1074/jbc.m114.604397

Authors


Horbelt, D More by this author
Boergermann, JH More by this author
Chaikuad, A More by this author
Williams, E More by this author
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Journal:
The Journal of biological chemistry
Publication date:
2014-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:1fbfafaa-d661-4f8c-9c52-ea997a8d240b
Source identifiers:
489694
Local pid:
pubs:489694

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