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Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase.

Abstract:

The Providencia stuartii AarA protein is a member of the rhomboid family of intramembrane serine proteases and is required for the production of an unknown quorum-sensing molecule. In a screen to identify rhomboid-encoding genes from Proteus mirabilis, tatA was identified as a multicopy suppressor and restored extracellular signal production as well as complementing all other phenotypes of a Prov. stuartii aarA mutant. TatA is a component of the twin-arginine translocase (Tat) protein secreti...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0608140104

Authors


Stevenson, LG More by this author
Strisovsky, K More by this author
Clemmer, KM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
104
Issue:
3
Pages:
1003-1008
Publication date:
2007-01-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:1fb88334-31f3-44bd-8c05-ff59637ae4a7
Source identifiers:
356140
Local pid:
pubs:356140

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