Journal article
Highly stereoselective oxy-michael additions to beta,gamma-unsaturated alpha-keto esters: rapid enantioselective synthesis of 3-hydroxybutenolides.
- Abstract:
- The highly diastereoselective oxy-Michael addition of the "naked" anion of (6S)-methyl delta-lactol to gamma-substituted beta,gamma-unsaturated alpha-keto esters leading to the direct formation of THP*-protected gamma-hydroxy alpha-keto ester derivatives is described. Subsequent acid-mediated deprotection affords the 3-hydroxybutenolides in high yields.
- Publication status:
- Published
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- Publisher copy:
- 10.1021/ol702693m
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Authors
Bibliographic Details
- Journal:
- Organic letters
- Volume:
- 10
- Issue:
- 4
- Pages:
- 565-567
- Publication date:
- 2008-02-01
- DOI:
- EISSN:
-
1523-7052
- ISSN:
-
1523-7060
- Source identifiers:
-
34105
Item Description
- Language:
- English
- Pubs id:
-
pubs:34105
- UUID:
-
uuid:1fb45910-9f58-408a-9383-9b35fe60627f
- Local pid:
- pubs:34105
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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