The impact of reducing the prostate-specific antigen threshold and including isoform reflex tests on the performance characteristics of a prostate-cancer detection programme.

Journal article

OBJECTIVE: To assess the effects on the performance characteristics, in a prostate-cancer detection programme using prostate-specific antigen (PSA) levels, of a lower PSA threshold and the incorporation of reflex (free or complexed PSA) tests. METHODS: We reviewed publications and extracted data on PSA distributions and performance characteristics of the PSA test and isoform tests from population-based surveys. We estimated the rate of biopsy, cancers detected, and cancers missed that would ...

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Authors: Roddam, A; Hamdy, F; Allen, N; Price, C

• Publication status: Published
• Journal: BJU international
• Volume: 100
• Issue: 3
• Pages: 514-517
• Publication date: 2007-09-01
• DOI: 10.1111/j.1464-410x.2007.07000.x
• EISSN: 1464-410X
• ISSN: 1464-4096
• Language: English
• Keywords: Prostatic Neoplasms; Prostate; Humans; Prostate-Specific Antigen; Sensitivity and Specificity; Middle Aged; Male; False Positive Reactions; UK Prostate Cancer Risk Management Programme; False Negative Reactions; Biopsy, Needle; Reference Values; Referral and Consultation; Aged; Protein Isoforms