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The impact of reducing the prostate-specific antigen threshold and including isoform reflex tests on the performance characteristics of a prostate-cancer detection programme.

Abstract:

OBJECTIVE: To assess the effects on the performance characteristics, in a prostate-cancer detection programme using prostate-specific antigen (PSA) levels, of a lower PSA threshold and the incorporation of reflex (free or complexed PSA) tests. METHODS: We reviewed publications and extracted data on PSA distributions and performance characteristics of the PSA test and isoform tests from population-based surveys. We estimated the rate of biopsy, cancers detected, and cancers missed that would ...

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Publication status:
Published

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Authors


Roddam, AW More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences, Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Cancer Epidemiology Unit
Journal:
BJU international
Volume:
100
Issue:
3
Pages:
514-517
Publication date:
2007-09-05
DOI:
EISSN:
1464-410X
ISSN:
1464-4096
URN:
uuid:1f9cb420-77ed-4878-a7b7-a9beaca99cea
Source identifiers:
66467
Local pid:
pubs:66467

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