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Journal article

The effect of hypointense white matter lesions on automated gray matter segmentation in multiple sclerosis.

Abstract:

Previous imaging studies assessing the relationship between white matter (WM) damage and matter (GM) atrophy have raised the concern that Multiple Sclerosis (MS) WM lesions may affect measures of GM volume by inducing voxel misclassification during intensity-based tissue segmentation. Here, we quantified this misclassification error in simulated and real MS brains using a lesion-filling method. Using this method, we also corrected GM measures in patients before comparing them with controls in...

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Publication status:
Published

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Publisher copy:
10.1002/hbm.21402

Authors


Gelineau-Morel, R More by this author
Tomassini, V More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Matthews, PM More by this author
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Journal:
Human brain mapping
Volume:
33
Issue:
12
Pages:
2802-2814
Publication date:
2012-12-05
DOI:
EISSN:
1097-0193
ISSN:
1065-9471
URN:
uuid:1f8a7d65-a206-4e1d-93de-1fbc4f7f0f59
Source identifiers:
242098
Local pid:
pubs:242098

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