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Journal article

Functional mapping of the N-terminal arginine cluster and C-terminal acidic residues of Kir6.2 channel fused to a G protein-coupled receptor

Abstract:

Ion channel-coupled receptors (ICCRs) are original man-made ligand-gated ion channels created by fusion of G protein-coupled receptors (GPCRs) to the inward-rectifier potassium channel Kir6.2. GPCR conformational changes induced by ligand binding are transduced into electrical current by the ion channel. This functional coupling is closely related to the length of the linker region formed by the GPCR C-terminus (C-ter) and Kir6.2 N-terminus (N-ter). Manipulating the GPCR C-ter length allows t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbamem.2017.07.015

Authors


More from this funder
Name:
National Institutes of Health
Grant:
N°EB007047
More from this funder
Name:
Agence Nationale de la Recherche
Grant:
ICCR project, grant ANR-09-PIRI-0010
More from this funder
Name:
Commissariat à l'énergie atomique et aux énergies alternatives
Publisher:
Elsevier
Journal:
Biochimica et Biophysica Acta (BBA) - Biomembranes More from this journal
Volume:
1859
Issue:
10
Pages:
2144-2153
Publication date:
2017-07-28
Acceptance date:
2017-07-26
DOI:
ISSN:
0006-3002
Language:
English
Keywords:
Pubs id:
pubs:713284
UUID:
uuid:1f8723bf-3313-4d24-9572-55ef907a2e52
Local pid:
pubs:713284
Source identifiers:
713284
Deposit date:
2017-08-12

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