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Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons.

Abstract:

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that carry out the fast actions of the neurotransmitter acetylcholine (ACh). Over the past 30 years, it has become clear that the activity of nAChRs is dependent on their interaction with a host of proteins, and the number of these that have been identified has increased considerably with recent large-scale proteomic analyses. This review focuses on these interacting proteins, discussing how they regulate a wide range of...

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Publication status:
Published

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Publisher copy:
10.1016/j.tips.2010.07.001

Authors


Buckingham, SD More by this author
Sattelle, DB More by this author
Journal:
Trends in pharmacological sciences
Volume:
31
Issue:
10
Pages:
455-462
Publication date:
2010-10-05
DOI:
EISSN:
1873-3735
ISSN:
0165-6147
URN:
uuid:1f7c7a8c-0cdf-44ae-97ce-a35fed3f979c
Source identifiers:
244261
Local pid:
pubs:244261

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