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Journal article

Structure and function of cohesin's Scc3/SA regulatory subunit

Abstract:

Sister chromatid cohesion involves entrapment of sister DNAs by a cohesin ring created through association of a kleisin subunit (Scc1) with ATPase heads of Smc1/Smc3 heterodimers. Cohesin's association with chromatin involves subunits recruited by Scc1: Wapl, Pds5, and Scc3/SA, in addition to Scc2/4 loading complex. Unlike Pds5, Wapl, and Scc2/4, Scc3s are encoded by all eukaryotic genomes. Here, a crystal structure of Scc3 reveals a hook-shaped protein composed of tandem α helices. Its N-ter...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
Cancer Research UK
Funding agency for:
Nasmyth, K
Grant:
C573/A 12386
More from this funder
Name:
Wellcome Trust
Funding agency for:
Nasmyth, K
Grant:
C573/A 12386
Publisher:
Elsevier
Journal:
FEBS Letters More from this journal
Volume:
588
Issue:
20
Pages:
3692-3702
Publication date:
2014-10-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Keywords:
Pubs id:
pubs:485851
UUID:
uuid:1f70656b-2b64-43b7-84eb-c146b415c99f
Local pid:
pubs:485851
Source identifiers:
485851
Deposit date:
2015-10-26

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