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Journal article

Enhanced TH17 responses in patients with IL10 receptor deficiency and infantile-onset IBD

Abstract:

Background

IL10 receptor (IL10R) deficiency causes severe infantile-onset IBD. Intact IL10R-dependent signals have been shown to be important for innate and adaptive immune cell function in mice. We have previously reported a key role of IL10 is the generation and function of human anti-inflammatory macrophages. Independent of innate immune cell defects, the aim of the current study was to determine the role of IL10R signaling in regulating human CD4+ T cell function.

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1097/mib.0000000000001270

Authors


Shouval, DS More by this author
Konnikova, L More by this author
Griffith, AE More by this author
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Crohn’s and Colitis Foundation of America More from this funder
Israel Science Foundation More from this funder
Helmsley Charitable Trust More from this funder
Wolpow Family Chair in IBD Treatment and Research More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Inflammatory Bowel Dseases Journal website
Volume:
23
Issue:
11
Pages:
1950-1961
Publication date:
2017-10-11
Acceptance date:
2017-07-15
DOI:
EISSN:
1536-4844
ISSN:
1078-0998
Pubs id:
pubs:736919
URN:
uri:1f705f3f-f209-44eb-b0f6-cee4aec02c20
UUID:
uuid:1f705f3f-f209-44eb-b0f6-cee4aec02c20
Local pid:
pubs:736919
Language:
English
Keywords:

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