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SETDB2 links glucocorticoid to lipid metabolism through Insig2a regulation

Abstract:

Transcriptional and chromatin regulations mediate the liver response to nutrient availability. The role of chromatin factors involved in hormonal regulation in response to fasting is not fully understood. We have identified SETDB2, a glucocorticoid-induced putative epigenetic modifier, as a positive regulator of GR-mediated gene activation in liver. Insig2a increases during fasting to limit lipid synthesis, but the mechanism of induction is unknown. We show Insig2a induction is GR-SETDB2 depe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-3153-617X
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Name:
National Heart, Lung, and Blood Institute, National Institutes of Health
Grant:
R01 HL048044
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Name:
American Heart Association/American Stroke Association
Grant:
12POST12040390
Publisher:
Elsevier
Journal:
Cell Metabolism More from this journal
Volume:
24
Issue:
3
Pages:
474-484
Publication date:
2016-08-25
Acceptance date:
2016-07-28
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
Pmid:
27568546

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