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The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection.

Abstract:

ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets. All members of the Coronavirinae, a subfamily of positive-sense RNA viruses, contain a highly conserved macrodomain within nonstructural protein 3 (nsp3). However, its function or targets during infection remain unknown. We identified several macrodoma...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/mBio.01721-16

Authors


Channappanavar, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Funding agency for:
Ahel, I
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Grant:
PO1 AI060699; RO1 AI091322
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Grant:
National Research Service Award F32-AI113973; T32-AI007260
Publisher:
American Society for Microbiology Publisher's website
Journal:
mBio Journal website
Volume:
7
Issue:
6
Pages:
e01721-16
Publication date:
2016-12-13
Acceptance date:
2016-11-16
DOI:
EISSN:
2150-7511
ISSN:
2161-2129
Pubs id:
pubs:666256
URN:
uri:1f5c7491-346d-47bb-8b8e-d0223084f31a
UUID:
uuid:1f5c7491-346d-47bb-8b8e-d0223084f31a
Local pid:
pubs:666256
Language:
English
Keywords:

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