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The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection.

Abstract:

ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets. All members of the Coronavirinae, a subfamily of positive-sense RNA viruses, contain a highly conserved macrodomain within nonstructural protein 3 (nsp3). However, its function or targets during infection remain unknown. We identified several macrodoma...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/mBio.01721-16

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
Ahel, I
Grant:
281739
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Funding agency for:
Ahel, I
Grant:
281739
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Grant:
National Research Service Award F32-AI113973
T32-AI007260
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Grant:
PO1 AI060699
RO1 AI091322
Publisher:
American Society for Microbiology Publisher's website
Journal:
mBio Journal website
Volume:
7
Issue:
6
Pages:
e01721-16
Publication date:
2016-12-13
Acceptance date:
2016-11-16
DOI:
EISSN:
2150-7511
ISSN:
2161-2129
Source identifiers:
666256
Language:
English
Keywords:
Pubs id:
pubs:666256
UUID:
uuid:1f5c7491-346d-47bb-8b8e-d0223084f31a
Local pid:
pubs:666256
Deposit date:
2017-04-26

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