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Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics

Abstract:

The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme-mediated methods remain of great interest in terms of synthetic utility. To date, known macrocyclization enzymes have been shown to be active on both peptide and protein substrates. Here we show that the macrocyclization enzyme of the cyanobactin family, PatGmac, is capable o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/anie.201601564

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Name:
Engineering and Physical Sciences Research Council
Grant:
*Grant Number Example*
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Name:
Royal Society
Funding agency for:
Naismith, J
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Name:
Wellcome Trust
Grant:
094476
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Name:
European Research Council
Grant:
339367
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Name:
Biotechnology and Biological Sciences Research Council
Grant:
K015508/1
Publisher:
Wiley
Journal:
Angewandte Chemie International Edition More from this journal
Volume:
55
Issue:
19
Pages:
5842-5845
Publication date:
2017-04-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Language:
English
Keywords:
Pubs id:
pubs:699016
UUID:
uuid:1f50c316-5a57-413c-b974-bfe920da199c
Local pid:
pubs:699016
Source identifiers:
699016
Deposit date:
2017-07-13

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