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Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics

Abstract:

The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme-mediated methods remain of great interest in terms of synthetic utility. To date, known macrocyclization enzymes have been shown to be active on both peptide and protein substrates. Here we show that the macrocyclization enzyme of the cyanobactin family, PatGmac, is capable o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/anie.201601564

Authors


Jaspars, M More by this author
Westwood, NJ More by this author
More by this author
Department:
Oxford, MSD, NDM
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Funding agency for:
Naismith, JH
Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie International Edition Journal website
Volume:
55
Issue:
19
Pages:
5842-5845
Publication date:
2017-04-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Pubs id:
pubs:699016
URN:
uri:1f50c316-5a57-413c-b974-bfe920da199c
UUID:
uuid:1f50c316-5a57-413c-b974-bfe920da199c
Local pid:
pubs:699016

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