Journal article
Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics
- Abstract:
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The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme-mediated methods remain of great interest in terms of synthetic utility. To date, known macrocyclization enzymes have been shown to be active on both peptide and protein substrates. Here we show that the macrocyclization enzyme of the cyanobactin family, PatGmac, is capable o...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 911.7KB)
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- Publisher copy:
- 10.1002/anie.201601564
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Authors
Funding
+ Engineering and Physical Sciences Research Council
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Angewandte Chemie International Edition Journal website
- Volume:
- 55
- Issue:
- 19
- Pages:
- 5842-5845
- Publication date:
- 2017-04-05
- DOI:
- EISSN:
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1521-3773
- ISSN:
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1433-7851
- Source identifiers:
-
699016
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:699016
- UUID:
-
uuid:1f50c316-5a57-413c-b974-bfe920da199c
- Local pid:
- pubs:699016
- Deposit date:
- 2017-07-13
Terms of use
- Copyright holder:
- © 2016 Oueis, et al
- Copyright date:
- 2017
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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