Journal article icon

Journal article

Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways

Abstract:

DNA double-strand breaks (DSBs), generated by ionizing radiation, reactive oxygen species and DNA replication across nicks, are the most severe DNA damage in eukaryotic cells. Non-Homologous End Joining repairs DNA double-strand breaks directly without a template and so can take place at any point in the cell cycle. Ku70/80 heterodimers rapidly assemble around broken DNA ends, allowing DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase, to be recruited and facilitating synapsis o...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.pbiomolbio.2019.03.007

Authors


More by this author
Role:
Author
ORCID:
0000-0001-8546-6341
More by this author
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0002-0348-7323
More from this funder
Name:
Wellcome Trust
Grant:
200814/Z/16/Z
Publisher:
Elsevier
Journal:
Progress in Biophysics and Molecular Biology More from this journal
Volume:
147
Pages:
26-32
Publication date:
2019-04-20
Acceptance date:
2019-03-26
DOI:
EISSN:
1873-1732
ISSN:
0079-6107
Pmid:
31014919
Language:
English
Keywords:
Pubs id:
995056
Local pid:
pubs:995056
Deposit date:
2020-03-09

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP