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Partitioning of large and minichromosomes in Trypanosoma brucei.

Abstract:

The Trypanosoma brucei nuclear genome contains about 100 minichromosomes of between 50 to 150 kilobases and about 20 chromosomes of 0.2 to 6 megabase pairs. Minichromosomes contain nontranscribed copies of variant surface glycoprotein (VSG) genes and are thought to expand the VSG gene pool. Varying VSG expression allows the parasite to avoid elimination by the host immune system. The mechanism of inheritance of T. brucei chromosomes was investigated by in situ hybridization in combination wit...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Science (New York, N.Y.)
Volume:
276
Issue:
5312
Pages:
611-614
Publication date:
1997-04-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:1f4b03e5-e8d4-4184-a341-1f524749ba6f
Source identifiers:
9491
Local pid:
pubs:9491

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