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Examining the statistical properties of fine-scale mapping in large-scale association studies.

Abstract:

Interpretation of dense single nucleotide polymorphism (SNP) follow-up of genome-wide association or linkage scan signals can be facilitated by establishing expectation for the behaviour of primary mapping signals upon fine-mapping, under both null and alternative hypotheses. We examined the inferences that can be made regarding the posterior probability of a real genetic effect and considered different disease-mapping strategies and prior probabilities of association. We investigated the imp...

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Publication status:
Published

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Publisher copy:
10.1002/gepi.20295

Authors


Wiltshire, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Zeggini, E More by this author
Journal:
Genetic epidemiology
Volume:
32
Issue:
3
Pages:
204-214
Publication date:
2008-04-05
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
URN:
uuid:1f429d57-e156-4e1b-bb5e-e3a08ce786e4
Source identifiers:
34071
Local pid:
pubs:34071

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