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Thesis

T cell phenotype and function in Spondyloarthritis

Abstract:

Th17 cells are implicated in a variety of inflammatory disorders including Spondyloarthritis (SpA). Ankylosing spondylitis (AS), the most common SpA, is genetically associated with HLA-B27 and IL-23R polymorphisms, although the link remains unexplained. In addition to classically folded heterotrimers, HLA-B27 can form β2m-free homodimers (B272). B272, as well as free heavy chains, are able to interact with KIR3DL2.

I have shown an expansion of KIR3DL2+ CD4+ T cells in peripheral blo...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Oriel College
Role:
Author

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Division:
MSD
Department:
NDM
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:1f3f6651-68f8-4bfa-89ee-15bb6d279ed3
Local pid:
ora:8022
Deposit date:
2014-02-17

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