Thesis
T cell phenotype and function in Spondyloarthritis
- Abstract:
-
Th17 cells are implicated in a variety of inflammatory disorders including Spondyloarthritis (SpA). Ankylosing spondylitis (AS), the most common SpA, is genetically associated with HLA-B27 and IL-23R polymorphisms, although the link remains unexplained. In addition to classically folded heterotrimers, HLA-B27 can form β2m-free homodimers (B272). B272, as well as free heavy chains, are able to interact with KIR3DL2.
I have shown an expansion of KIR3DL2+ CD4+ T cells in peripheral blo...
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Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:1f3f6651-68f8-4bfa-89ee-15bb6d279ed3
- Local pid:
- ora:8022
- Deposit date:
- 2014-02-17
Terms of use
- Copyright holder:
- Anna Ridley
- Copyright date:
- 2013
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