The germinal center (GC) reaction produces high-affinity antibodies by random mutation and selective clonal expansion of B cells with high-affinity receptors. The mechanism by which B cells are selected remains unclear, as does the role of the two anatomically defined areas of the GC, light zone (LZ) and dark zone (DZ). We combined a transgenic photoactivatable fluorescent protein tracer with multiphoton laser-scanning microscopy and flow cytometry to examine anatomically defined LZ and DZ B ...Expand abstract
- Publisher copy:
- Copyright date:
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record