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Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.

Abstract:

The germinal center (GC) reaction produces high-affinity antibodies by random mutation and selective clonal expansion of B cells with high-affinity receptors. The mechanism by which B cells are selected remains unclear, as does the role of the two anatomically defined areas of the GC, light zone (LZ) and dark zone (DZ). We combined a transgenic photoactivatable fluorescent protein tracer with multiphoton laser-scanning microscopy and flow cytometry to examine anatomically defined LZ and DZ B ...

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Publisher copy:
10.1016/j.cell.2010.10.032

Authors


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Journal:
Cell
Volume:
143
Issue:
4
Pages:
592-605
Publication date:
2010-11-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:1f3da1f8-fa7d-44a7-aa91-5862cb6f4f37
Source identifiers:
426274
Local pid:
pubs:426274

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