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The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours.

Abstract:

In a previous study of phyllodes tumours, it has been shown that both the stroma and the epithelium can exhibit distinct molecular changes, suggesting that both are part of the neoplastic process. In view of this finding, it was decided to study stromal-epithelial interactions in these tumours by examining the Wnt-APC-beta-catenin pathway. Beta-catenin and cyclin D1 immunohistochemistry was performed on 119 phyllodes tumours. Eighty-six (72%) showed stromal nuclear beta-catenin localization a...

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Publisher copy:
10.1002/path.1067

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Journal:
Journal of pathology More from this journal
Volume:
196
Issue:
4
Pages:
437-444
Publication date:
2002-04-01
DOI:
EISSN:
1096-9896
ISSN:
0022-3417

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