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Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents

Abstract:

One function of N-linked glycans is to assist in the folding of glycoproteins by mediating interactions of the lectin-like chaperone proteins calnexin and calreticulin with nascent glycoproteins. These interactions can be prevented by inhibitors of thea-glucosidases, such asN-butyl-deoxynojirimycin (NB-DNJ) and N-nonylDNJ (NN-DNJ), and this causes some proteins to be misfolded and retained within the endoplasmic reticulum (ER). We have shown previously that the NN-DNJ-induced misfolding of on...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.96.21.11878

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proc. Natl. Acad. Sci. U.S.A. Journal website
Volume:
96
Pages:
11878-11882
Publication date:
1999-01-01
DOI:
URN:
uuid:1f317da6-867b-4679-976e-4ee1252b6194
Source identifiers:
383424
Local pid:
pubs:383424

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