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Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.

Abstract:

BACKGROUND: Research for the use of biomarkers in osteoarthritis (OA) is promising, however, adequate discrimination between patients and controls may be hampered due to innate differences. We set out to identify loci influencing levels of serum cartilage oligomeric protein (sCOMP) and urinary C-telopeptide of type II collagen (uCTX-II). METHODS: Meta-analysis of genome-wide association studies was applied to standardised residuals of sCOMP (N=3316) and uCTX-II (N=4654) levels available in 6 ...

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Publication status:
Published

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Publisher:
BMJ Publishing Group
Journal:
Journal of medical genetics
Volume:
51
Issue:
9
Pages:
596-604
Publication date:
2014-09-05
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
URN:
uuid:1f2fea06-4f44-4761-8683-eadb5d5252b4
Source identifiers:
477591
Local pid:
pubs:477591
Language:
English
Keywords:

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