Red cell and platelet-derived microparticles are increased in G6PD-deficient subjects.

Journal article

In response to oxidative stress and during apoptosis, cells often shed microparticles (MPs), submicron elements carrying phosphatidylserine and protein antigens. Glucose-6-phosphate dehydrogenase (G6PD)-deficient cells are extremely sensitive to oxidative damage that may lead to the formation of MPs. To determine whether G6PD deficiency alters membrane phospholipid asymmetry and increases MPs production, we determined the concentrations and cellular origins of MPs in G6PD-deficient individual...

Expand abstract

Authors: Nantakomol, D; Palasuwan, A; Chaowanathikhom, M; Soogarun, S; Imwong, M

• Journal: European journal of haematology
• Volume: 89
• Issue: 5
• Pages: 423-429
• Publication date: 2012-11-01
• DOI: 10.1111/ejh.12010
• EISSN: 1600-0609
• ISSN: 0902-4441
• Language: English
• Keywords: Case-Control Studies; Adolescent; Glucosephosphate Dehydrogenase; Young Adult; Blood Platelets; Oxidative Stress; Mutation; Microscopy, Atomic Force; Humans; Reference Values; Adult; Female; Middle Aged; Cell-Derived Microparticles; Flow Cytometry; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Male