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Red cell and platelet-derived microparticles are increased in G6PD-deficient subjects.

Abstract:

In response to oxidative stress and during apoptosis, cells often shed microparticles (MPs), submicron elements carrying phosphatidylserine and protein antigens. Glucose-6-phosphate dehydrogenase (G6PD)-deficient cells are extremely sensitive to oxidative damage that may lead to the formation of MPs. To determine whether G6PD deficiency alters membrane phospholipid asymmetry and increases MPs production, we determined the concentrations and cellular origins of MPs in G6PD-deficient individual...

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Publisher copy:
10.1111/ejh.12010

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
European journal of haematology More from this journal
Volume:
89
Issue:
5
Pages:
423-429
Publication date:
2012-11-01
DOI:
EISSN:
1600-0609
ISSN:
0902-4441
Language:
English
Keywords:
Pubs id:
pubs:350537
UUID:
uuid:1f2a20f6-9136-41fb-ae2d-c5b0d25edf0a
Local pid:
pubs:350537
Source identifiers:
350537
Deposit date:
2013-11-16

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