Journal article
Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic–hydrophilic copolymers
- Abstract:
-
The aim of this study was to evaluate the use of cationic–hydrophilic copolymers for self-assembly with antisense oligonucleotides targeted to the bcl-2 mRNA in order to improve their biocompatibility and modulation of their pharmacokinetics for greater therapeutic usefulness. Examination of the ability of poly(trimethylammonioethyl methacrylate chloride)–poly[N-(2-hydroxypropyl)methacrylamide] (pHPMA-b-pTMAEM) block copolymers to condense the oligonucleotide ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1016/S0928-0987(00)00069-5
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Authors
Contributors
+ Seymour, L
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Contributor
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- European Journal of Pharmaceutical Sciences Journal website
- Volume:
- 10
- Issue:
- 3
- Pages:
- 169-177
- Publication date:
- 2000-04-12
- Acceptance date:
- 1999-11-25
- DOI:
- EISSN:
-
1879-0720
- ISSN:
-
0928-0987
- Source identifiers:
-
709415
Item Description
- Keywords:
- Pubs id:
-
pubs:709415
- UUID:
-
uuid:1f29021a-43c6-40bf-8f28-5f7ac318b108
- Local pid:
- pubs:709415
- Deposit date:
- 2017-07-27
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2000
- Notes:
- © 2000 Elsevier Science B.V. All rights reserved.
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