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Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic–hydrophilic copolymers

Abstract:

The aim of this study was to evaluate the use of cationic–hydrophilic copolymers for self-assembly with antisense oligonucleotides targeted to the bcl-2 mRNA in order to improve their biocompatibility and modulation of their pharmacokinetics for greater therapeutic usefulness. Examination of the ability of poly(trimethylammonioethyl methacrylate chloride)–poly[N-(2-hydroxypropyl)methacrylamide] (pHPMA-b-pTMAEM) block copolymers to condense the oligonucleotide ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Contributor
Publisher:
Elsevier Publisher's website
Journal:
European Journal of Pharmaceutical Sciences Journal website
Volume:
10
Issue:
3
Pages:
169-177
Publication date:
2000-04-12
Acceptance date:
1999-11-25
DOI:
EISSN:
1879-0720
ISSN:
0928-0987
Source identifiers:
709415
Keywords:
Pubs id:
pubs:709415
UUID:
uuid:1f29021a-43c6-40bf-8f28-5f7ac318b108
Local pid:
pubs:709415
Deposit date:
2017-07-27

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