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A sperm-specific proteome-scale metabolic network model identifies non-glycolytic genes for energy deficiency in asthenozoospermia

Abstract:

About 15% of couples experience difficulty in conceiving a child, of which half of the cases are thought to be male-related. Asthenozoospermia, or low sperm motility, is one of the frequent types of male infertility. Although energy metabolism is suggested to be central to the etiology of asthenozoospermia, very few attempts have been made to identify its underlying metabolic pathways. Here, we reconstructed SpermNet, the first proteome-scale model of the sper...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-9801-7449
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0003-0908-0484
Publisher:
Taylor and Francis Publisher's website
Journal:
Systems Biology in Reproductive Medicine Journal website
Volume:
63
Issue:
2
Pages:
100-112
Publication date:
2017-01-13
Acceptance date:
2016-10-01
DOI:
EISSN:
1939-6376
ISSN:
1939-6368
Pmid:
28085499
Source identifiers:
827867
Language:
English
Keywords:
Pubs id:
pubs:827867
UUID:
uuid:1f26ae3c-26e4-4021-8a70-6943920723bc
Local pid:
pubs:827867
Deposit date:
2018-03-08

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