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Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1.

Abstract:

Spinocerebellar ataxia type 1 (SCA1) is a hereditary, progressive and fatal movement disorder that primarily affects the cerebellum. Non-invasive imaging markers to detect early disease in SCA1 will facilitate testing and implementation of potential therapies. We have previously demonstrated the sensitivity of neurochemical levels measured by (1) H magnetic resonance spectroscopy (MRS) to progressive neurodegeneration using a transgenic mouse model of SCA1. In order to investigate very early ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1111/jnc.12435

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Brent Clark, H More by this author
Vollmers, ML More by this author
Eberly, LE More by this author
Publisher:
Wiley Online Library Publisher's website
Journal:
Journal of neurochemistry Journal website
Volume:
127
Issue:
5
Pages:
660-668
Publication date:
2013-09-17
Acceptance date:
2013-08-27
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:1f1ddcd5-314d-47c4-b3d0-09295870bd3e
Source identifiers:
457579
Local pid:
pubs:457579

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