Journal article
An individual participant data population pharmacokinetic meta-analysis of drug-drug interactions between lumefantrine and commonly used antiretroviral treatment
- Abstract:
-
Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population pharmacokinetic meta-analysis was conducted using individual participant data from 10 studies with 6,100 lumefantrine concentrations from 793 nonpregnant adult participants (41%...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Antimicrobial Agents and Chemotherapy Journal website
- Volume:
- 64
- Issue:
- 5
- Article number:
- e02394-19
- Publication date:
- 2020-04-21
- Acceptance date:
- 2020-02-04
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- Pmid:
-
32071050
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1092793
- Local pid:
- pubs:1092793
- Deposit date:
- 2020-07-21
Terms of use
- Copyright holder:
- Francis et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Francis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- Licence:
- CC Attribution (CC BY)
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