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AFM observation of single, functioning ionotropic glutamate receptors reconstituted in lipid bilayers.

Abstract:

BACKGROUND: Ionotropic glutamate receptors (iGluRs) are responsible for extracellular signaling in the central nervous system. However, the relationship between the overall structure of the protein and its function has yet to be resolved. Atomic force microscopy (AFM) is an important technique that allows nano-scale imaging in liquid. In the present work we have succeeded in imaging by AFM of the external features of the most common iGluR, AMPA-R (alpha-amino-3-hydroxy-5-methyl-4-isoxazole p...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
Journal:
Biochimica et biophysica acta More from this journal
Volume:
1800
Issue:
7
Pages:
655-661
Publication date:
2010-07-01
DOI:
ISSN:
0006-3002
Language:
English
Keywords:
Pubs id:
pubs:65328
UUID:
uuid:1f182b03-8f3c-4384-9049-1af4edbdc5f4
Local pid:
pubs:65328
Source identifiers:
65328
Deposit date:
2012-12-19

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