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Journal article

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis.

Abstract:

Hypoxia-inducible factor-1 (HIF) is a transcription factor central to oxygen homeostasis. It is regulated via its alpha isoforms. In normoxia they are ubiquitinated by the von Hippel-Lindau E3 ligase complex and destroyed by the proteasome, thereby preventing the formation of an active transcriptional complex. Oxygen-dependent enzymatic hydroxylation of either of two critical prolyl residues in each HIFalpha chain has recently been identified as the modification necessary for targeting by the...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.162119399

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Mahmood, SA More by this author
Wilson, MI More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
99
Issue:
16
Pages:
10423-10428
Publication date:
2002-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:1f17c8a1-4ce3-45ac-8fdb-bb563c93fa99
Source identifiers:
29169
Local pid:
pubs:29169

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