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A method for reproducible measurements of serum BDNF: comparison of the performance of six commercial assays

Abstract:

Brain-Derived Neurotrophic Factor (BDNF) has attracted increasing interest as potential biomarker to support the diagnosis or monitor the efficacy of therapies in brain disorders. Circulating BDNF can be measured in serum, plasma or whole blood. However, the use of BDNF as biomarker is limited by the poor reproducibility of results, likely due to the variety of methods used for sample collection and BDNF analysis. To overcome these limitations, using sera from 40 healthy adults, we compared t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep17989

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Department:
Unknown
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
5
Issue:
1
Publication date:
2015-12-10
Acceptance date:
2015-11-10
DOI:
ISSN:
2045-2322
Source identifiers:
1013560
Language:
English
Keywords:
Pubs id:
pubs:1013560
UUID:
uuid:1f11cdef-3779-49c6-aa1c-25ddc4482ff9
Local pid:
pubs:1013560
Deposit date:
2019-06-14

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