Gene expression profiling of the retina after transcorneal electrical stimulation in wild-type Brown Norway rats.

Journal article

PURPOSE: Transcorneal electrical stimulation (TES) has been beneficial in several neurodegenerative ocular diseases, but the exact mechanisms remain to be elucidated. This study was conducted to investigate the effects of TES on the retinas of wild-type Brown Norway (BN) rats by gene expression profiling and to assess its effects on retinal function and morphology. METHODS: TES was applied to BN wild-type rat retinas in vivo for 1 hour (1-ms biphasic pulses at 20 Hz; 200 μA). RNA was isolate...

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Authors: Willmann, G; Schäferhoff, K; Fischer, M; Arango-Gonzalez, B; Bolz, S

• Journal: Investigative ophthalmology and visual science
• Volume: 52
• Issue: 10
• Pages: 7529-7537
• Publication date: 2011-09-01
• DOI: 10.1167/iovs.11-7838
• EISSN: 1552-5783
• ISSN: 0146-0404
• Language: English
• Keywords: Male; Rats; Gene Expression Regulation; Retina; Immunohistochemistry; Rats, Inbred BN; Electroretinography; Gene Expression Profiling; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Animals; Cornea; Tomography, Optical Coherence; Electric Stimulation