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Gene expression profiling of the retina after transcorneal electrical stimulation in wild-type Brown Norway rats.

Abstract:

PURPOSE: Transcorneal electrical stimulation (TES) has been beneficial in several neurodegenerative ocular diseases, but the exact mechanisms remain to be elucidated. This study was conducted to investigate the effects of TES on the retinas of wild-type Brown Norway (BN) rats by gene expression profiling and to assess its effects on retinal function and morphology. METHODS: TES was applied to BN wild-type rat retinas in vivo for 1 hour (1-ms biphasic pulses at 20 Hz; 200 μA). RNA was isolate...

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Publisher copy:
10.1167/iovs.11-7838

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Investigative ophthalmology and visual science
Volume:
52
Issue:
10
Pages:
7529-7537
Publication date:
2011-09-05
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
URN:
uuid:1f10b77b-138c-4fc7-a9ba-d533e56b97f4
Source identifiers:
372031
Local pid:
pubs:372031

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