Journal article
Alterations in brain connectivity underlying beta oscillations in Parkinsonism.
- Abstract:
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Cortico-basal ganglia-thalamocortical circuits are severely disrupted by the dopamine depletion of Parkinson's disease (PD), leading to pathologically exaggerated beta oscillations. Abnormal rhythms, found in several circuit nodes are correlated with movement impairments but their neural basis remains unclear. Here, we used dynamic causal modelling (DCM) and the 6-hydroxydopamine-lesioned rat model of PD to examine the effective connectivity underlying these spectral abnormalities. We acquire...
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- Publication status:
- Published
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(pdf, 1.5MB)
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- Publisher copy:
- 10.1371/journal.pcbi.1002124
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Authors
Bibliographic Details
- Journal:
- PLoS computational biology
- Volume:
- 7
- Issue:
- 8
- Pages:
- e1002124
- Publication date:
- 2011-08-11
- DOI:
- EISSN:
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1553-7358
- ISSN:
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1553-734X
- Source identifiers:
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179684
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:1f0f93e1-7fd4-4050-923e-2ce4a3da46e6
- Local pid:
- pubs:179684
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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