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Journal article

Alterations in brain connectivity underlying beta oscillations in Parkinsonism.

Abstract:

Cortico-basal ganglia-thalamocortical circuits are severely disrupted by the dopamine depletion of Parkinson's disease (PD), leading to pathologically exaggerated beta oscillations. Abnormal rhythms, found in several circuit nodes are correlated with movement impairments but their neural basis remains unclear. Here, we used dynamic causal modelling (DCM) and the 6-hydroxydopamine-lesioned rat model of PD to examine the effective connectivity underlying these spectral abnormalities. We acquire...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pcbi.1002124

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Sub department:
BNDU
Role:
Author
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Journal:
PLoS computational biology
Volume:
7
Issue:
8
Pages:
e1002124
Publication date:
2011-08-11
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Source identifiers:
179684
Language:
English
Keywords:
UUID:
uuid:1f0f93e1-7fd4-4050-923e-2ce4a3da46e6
Local pid:
pubs:179684
Deposit date:
2012-12-19

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