Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual.

Journal article

Evidence is accruing that environmental exposures during critical periods of early development induce persisting changes in skeletal growth, and alter fracture risk in later life. We have previously demonstrated that placental calcium transport, partly determined by maternal 25-(OH) vitamin D status, may underlie this phenomenon. However, the precise relationship between expression of calcium transport proteins in the human placenta, and neonatal bone mineral accrual in the offspring, remains...

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Authors: Martin, R; Harvey, N; Crozier, SR; Poole, JR; Javaid, M

• Publication status: Published
• Journal: Bone
• Volume: 40
• Issue: 5
• Pages: 1203-1208
• Publication date: 2007-05-01
• DOI: 10.1016/j.bone.2006.12.060
• EISSN: 1873-2763
• ISSN: 8756-3282
• Language: English
• Keywords: Female; Humans; Mothers; Life Style; Bone Density; Plasma Membrane Calcium-Transporting ATPases; Infant, Newborn; Birth Weight; Uterus; RNA, Messenger; Gene Expression Regulation; Body Height; SWS Study Group; Male; Body Composition; Time Factors; Gestational Age; Pregnancy; Adult