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Cluster analysis of bone microarchitecture from high resolution peripheral quantitative computed tomography demonstrates two separate phenotypes associated with high fracture risk in men and women.

Abstract:

Osteoporosis is a major healthcare problem which is conventionally assessed by dual energy x-ray absorptiometry (DXA). New technologies such as high resolution peripheral quantitative computed tomography (HRpQCT) also predict fracture risk. HRpQCT measures a number of bone characteristics that may inform specific patterns of bone deficits. We used cluster analysis to define different bone phenotypes and their relationships to fracture prevalence and areal bone mineral density (BMD). 177...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bone.2016.04.025

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Name:
Medical Research Council
Grant:
U105960371
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Name:
Arthritis Research UK
Grant:
19583
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Name:
National Institute for Health Research
Publisher:
Elsevier
Journal:
Bone More from this journal
Volume:
88
Pages:
131-137
Publication date:
2016-04-01
Acceptance date:
2016-04-25
DOI:
EISSN:
8756-3282
ISSN:
1873-2763
Pmid:
27130873
Language:
English
Keywords:
Pubs id:
pubs:619563
UUID:
uuid:1f0d9aad-1234-48c4-bcf1-a02d18a3f6aa
Local pid:
pubs:619563
Source identifiers:
619563
Deposit date:
2017-01-20

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