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HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.

Abstract:

Mutational escape from the CTL response represents a major driving force for viral diversification in HIV-1-infected adults, but escape during infancy has not been described previously. We studied the immune response of perinatally infected children to an epitope (B57-TW10) that is targeted early during acute HIV-1 infection in adults expressing HLA-B57 and rapidly mutates under this selection pressure. Viral sequencing revealed the universal presence of escape mutations within TW10 among B57...

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Publication status:
Published

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
174
Issue:
12
Pages:
7524-7530
Publication date:
2005-06-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:1efb0801-2e44-4608-9be2-9fb31df716a7
Source identifiers:
14992
Local pid:
pubs:14992

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