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Acetylcholine and norepinephrine stimulate the release of corticotropin-releasing factor-41 from the rat hypothalamus in vitro.

Abstract:

The effects of the two putative neurotransmitters acetylcholine and norepinephrine on immunoreactive CRF-41 release from incubated rat hypothalami were studied. Acetylcholine at concentrations of 10(-11) to 10(-7) M stimulated CRF-41 release. This effect was blocked in a dose-dependent manner by the muscarinic antagonist atropine (10(-9) to (-7) M). The nicotinic antagonist hexamethonium was ineffective at a dose of 10(-7) M, but produced slight inhibition of this response at 10(-5) M. Norepi...

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Publication status:
Published

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Publisher copy:
10.1210/endo-123-4-1962

Authors


Tsagarakis, S More by this author
Besser, GM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Endocrinology
Volume:
123
Issue:
4
Pages:
1962-1969
Publication date:
1988-10-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:1ef51312-e305-4fad-97a0-f33ff058de61
Source identifiers:
138400
Local pid:
pubs:138400

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