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Occupancy and mechanism in antibody-mediated neutralization of animal viruses.

Abstract:

Neutralization of virus infectivity by antibodies is an important component of immunity to several virus infections. Here, the immunochemical basis for the action of neutralizing antibodies, and what role their induction of conformational changes in the antigen might play, is reviewed. Theories of the mechanisms by which antibodies neutralize virus infectivity in vitro are also presented. The theoretical and empirical foundation of the hypothesis that viruses are neutralized by a single antib...

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Publication status:
Published

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Publisher copy:
10.1099/vir.0.18242-0

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
Journal of general virology
Volume:
83
Issue:
Pt 9
Pages:
2091-2108
Publication date:
2002-09-01
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
Source identifiers:
27255
Language:
English
Keywords:
Pubs id:
pubs:27255
UUID:
uuid:1ef50879-e940-4b80-8ee8-2dc33bb43201
Local pid:
pubs:27255
Deposit date:
2012-12-19

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