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Journal article

Prevalence of BRCA1 and BRCA2 pathogenic variants in a large, unselected breast cancer cohort

Abstract:

Breast cancer patients with BRCA1/2‐driven tumors may benefit from targeted therapy. It is not clear whether current BRCA screening guidelines are effective at identifying these patients. The purpose of our study was to evaluate the prevalence of inherited BRCA1/2 pathogenic variants in a large, clinically representative breast cancer cohort and to estimate the proportion of BRCA1/2 carriers not detected by selectively screening individuals with the highest probability of being carriers accor...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1002/ijc.31841

Authors


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Role:
Author
ORCID:
0000-0001-8587-7511
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Oxford college:
University College
Role:
Author
Publisher:
Wiley
Journal:
International Journal of Cancer More from this journal
Volume:
144
Issue:
5
Pages:
1195-1204
Publication date:
2018-09-02
Acceptance date:
2018-08-09
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Language:
English
Keywords:
Pubs id:
pubs:965427
UUID:
uuid:1eedf81b-4647-468b-8f7f-068b676b2f47
Local pid:
pubs:965427
Source identifiers:
965427
Deposit date:
2019-01-20

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